Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study. J Natl Cancer Inst 2000;92:1910–1917

Background: Recent studies have suggested that men with elevated plasma levels of insulin-like growth factor-I (IGF-I) may have an increased risk of prostate cancer. Furthermore, IGF-binding proteins (IGFBPs) and insulin can modulate the activity of IGF-I. In this study, we sought to determine the r...

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Bibliographic Details
Main Authors: Annika Bylund, Sabina Rinaldi, Carine Biessy, Ulf-håkan Stenman, Lars Egevad, Elio Riboli, Rudolf Kaaks
Other Authors: The Pennsylvania State University CiteSeerX Archives
Format: Text
Language:English
Subjects:
Northern Sweden
Online Access:http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.629.4091
http://jnci.oxfordjournals.org/content/92/23/1910.full.pdf
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Summary:Background: Recent studies have suggested that men with elevated plasma levels of insulin-like growth factor-I (IGF-I) may have an increased risk of prostate cancer. Furthermore, IGF-binding proteins (IGFBPs) and insulin can modulate the activity of IGF-I. In this study, we sought to determine the role of IGF-I as well as IGFBPs-1,-2, and-3 and insulin as possible etiologic factors for prostate cancer. Methods: We conducted a nested case–control study within the Northern Sweden Health and Disease Cohort Study. We measured

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