The prevalence of type 2 diabetes andimpaired glucose tolerance (IGT) inadult Ontario Oji-Cree Indians approaches 40%, which is the third high-est of any subpopulation in the world and is,5 times higher than the prevalence observed in the general Canadian popula-tion (1). The complications of type 2...
| Other Authors: | |
|---|---|
| Format: | Text |
| Language: | English |
| Subjects: | |
| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.618.360 http://care.diabetesjournals.org/content/23/6/775.full.pdf |
| Summary: | The prevalence of type 2 diabetes andimpaired glucose tolerance (IGT) inadult Ontario Oji-Cree Indians approaches 40%, which is the third high-est of any subpopulation in the world and is,5 times higher than the prevalence observed in the general Canadian popula-tion (1). The complications of type 2 dia-betes in the Oji-Cree are anticipated to soon extract a substantial social and eco-nomic toll. The high prevalence of dia-betes will also challenge existing health care delivery paradigms because the,30,000 Oji-Cree who live on reserva-tions in northwestern Ontario and in Manitoba, Canada, are dispersed across a wide, remote, and harsh area. Intervention strategies to prevent or delay the onset of type 2 diabetes and its complications would include the modification of diet and lifestyle in high-risk subjects because diet and lifestyle appear to contribute to the expression of type 2 diabetes suscep-tibility in the Oji-Cree (1). We recently identified a private HNF1A mutation, G319S, that was very strongly associated with type 2 diabetes in the Oji-Cree (2,3). The HNF1A S319 allele was present in.40 % of the Oji-Cree who had diabetes and was associated with an earlier age at onset of diabetes (2,3), adolescent-onset type 2 diabetes (4), and changes in plasma lipoproteins (5). HNF1A S319 car-riers had a phenotype that resembled typi-cal type 2 diabetes and not maturity-onset diabetes of the young, which can also result from HNF1A mutations (2–5). Whatever the mechanistic basis for its association with type 2 diabetes, the HNF1A G319S genotype appears to be potentially useful as a predictive test for type 2 diabetes in the Oji-Cree. The availability of such a predictive test would be important because it may help to identify high-risk subjects at the presymptomatic stage who may benefit from intervention strategies. In the present study, we evaluated the HNF1A genotype as a clinical test for the prediction of type 2 diabetes in the Oji-Cree of northern Ontario. We evaluated Oji-Cree residents of the Sandy Lake ... |
|---|