EFFECTS OF ADENOSINE IN THE BRANCHIAL CIRCULATION OF A. anguilla AND S. acanthias: INVOLVEMENT OF NO
Adenosine (AD) is a potent vasoactive modulator that in mammals dilates systemic, coronary and cerebral vasculatures (Collis, 1989), whereas can exert a constrictor actions in several lung vessel preparations (Lippton et al., 1982). In fish, the scant data indicate variable vasomotive actions of AD,...
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.608.7033 http://www-heb.pac.dfo-mpo.gc.ca/congress/2002/Cardiovasc/Pellegrino.pdf |
| Summary: | Adenosine (AD) is a potent vasoactive modulator that in mammals dilates systemic, coronary and cerebral vasculatures (Collis, 1989), whereas can exert a constrictor actions in several lung vessel preparations (Lippton et al., 1982). In fish, the scant data indicate variable vasomotive actions of AD, ranging from vasodilation in hagfish (Myxine glutinosa) gills ( Axelsson et al., 1990) to vasoconstriction in the gills of Oreochromis niloticus (Okafor and Oduleye (1986) and rainbow trout (Oncorhynchus mykiss) (Sundin and Nilsson, 1996). In the swim bladder vessels of Anguilla anguilla (Schwerte et al., 1999) and in the intact coronary tree of the trout (Oncorhynchus mykiss) (Mustafa and Agnisola, 1998), AD exerts vasodilation. In mammals, the cardiovascular effects of AD are primarily mediated by A1 and A2 receptors, the former causing vasoconstriction and the latter inducing vasodilatation (Ralevic et al., 1998). In the ventral aorta of the dogfish Squalus acanthias, in which both receptors have been detected, the A1 elicited contraction while the A2 mediated relaxation (Evans, 1992). |
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