ORIGINAL CONTRIBUTION Relationship Between Serum Parathyroid Hormone Levels, Vitamin D Sufficiency, and Calcium Intake
THE IMPORTANCE OF ADEQUATEvitamin D status for optimumbone health has received in-creased recognition in recent years, with higher recommended in-take levels being proposed by some in-vestigators.1-3 The ideal intake is not known, and different criteria have been proposed for estimating population r...
| Main Authors: | , , , |
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| Format: | Text |
| Language: | English |
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.581.266 http://www.direct-ms.org/pdf/VitDGenScience/PTHCaVitD.pdf |
| Summary: | THE IMPORTANCE OF ADEQUATEvitamin D status for optimumbone health has received in-creased recognition in recent years, with higher recommended in-take levels being proposed by some in-vestigators.1-3 The ideal intake is not known, and different criteria have been proposed for estimating population re-quirements. Serum 25-hydroxyvita-min D has been the generally accepted indicator of vitaminDstatus, but nouni-versal consensus has been reached re-garding which serum values constitute sufficiency.4,5 A further difficulty in as-signing a universal reference valuemay lie in the interrelationship between sev-eral factors influencing calciumhomeo-stasis, not the least being the 2 nutri-ents vitamin D and calcium. An inverse relationship between se-rum 25-hydroxyvitamin D and serum parathyroid hormone (PTH) is well es-tablished, up to a certain level of 25-hydroxyvitamin D, in which little fur-ther decrease in serumPTH is observed. The serum level for 25-hydroxyvita-min D corresponding with the PTH in-flection point has been interpreted as indicative of optimal calcium homeo-stasis and proposed as a marker of vi-taminD sufficiency.5,6 However, this ap-proach to defining recommended vitamin D intake has been disputed, partly because there is considerable variation in the level of 25-hydroxyvi-tamin D associated with any given se- |
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