1 USE AND MISUSE OF DIETARY FATTY ACIDS FOR THE PREVENTION AND TREATMENT OF CORONARY HEART DISEASE
2 Since Scandinavian investigators suggested that the low mortality rate from coronary heart disease (CHD) among Greenland Eskimos as compared to Europeans might be due to their diet including large quantities of seafood (1), the health effects of fish (and n-3 fatty acids) have attracted considerab...
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| Language: | English |
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.5060 http://www.1stvitality.co.uk/pdfs/Prof_de_lorgeril.pdf |
| Summary: | 2 Since Scandinavian investigators suggested that the low mortality rate from coronary heart disease (CHD) among Greenland Eskimos as compared to Europeans might be due to their diet including large quantities of seafood (1), the health effects of fish (and n-3 fatty acids) have attracted considerable scientific interest. Meanwhile, most epidemiological studies have demonstrated a protective effect linked to the consumption of even small amounts of fish. However, the controversy surrounding the association between fish consumption and CHD was revived by the recent publication of negative results in two large cohort studies in the USA (2,3) and by the inconsistent findings of another two studies (4,5). This apparent inconsistency in results could be due to: 1) differences in the methods of dietary assessment of fish intake (4); 2) different mixes of fish types in the diet, for instance fatty fish versus lean fish, as well as different geographic origins of the fish (5); 3) potential contamination of fish by toxic heavy metals in certain areas (6); 4) possible bias due to CHD patients (or subjects at high risk of CHD) being aware that fish consumption is cardioprotective, which may result in a reversal of the fish eating-CHD relationship from "cause-effect " to "effect-cause " (2,3); 5) differences in |
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