The vitamin D receptor and its ligand 1a,25-dihydroxyvitamin D3 in, R
ijm vers.nl) D receptor (sVDR0) and two alternatively spliced variants the vitamin D system plays a crucial role in calcium and proliferator activator receptor, thyroid hormone, and retinoic acid receptors (DeLuca & Zierold 1998, Issa et al. 1998, Jones is under strict control of calcitriol (Dar...
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.2109 http://joe.endocrinology-journals.org/content/193/3/459.full.pdf |
| Summary: | ijm vers.nl) D receptor (sVDR0) and two alternatively spliced variants the vitamin D system plays a crucial role in calcium and proliferator activator receptor, thyroid hormone, and retinoic acid receptors (DeLuca & Zierold 1998, Issa et al. 1998, Jones is under strict control of calcitriol (Darwish & DeLuca 1992, concentration (MacIntyre et al. 1976), and in American eel, Anguilla rostrata, it increased intestinal calcium absorption water calcium concentration. Dietary calcium load may 459Journal of Endocrinology (2007) 193, 459–471Bronner & Pansu 1998). Reabsorption of Ca in the kidney is partly dependent on calcitriol and the VDR. Another decrease branchial uptake to avoid overload and to ensure the required net influx for homeostasis and growth. In addition, DOI:10.1677/JOE-06-0198et al. 1998). Low serum levels of calcitriol cause type I rickets; the absence of the VDR results in type II rickets (Yagishita et al. 2001, Pettifor 2004). Several genes involved in control of calcium uptake are regulated by vitamin D, e.g. synthesis of calbindin D9K, involved in active intestinal calcium transport, (Fenwick et al. 1984). This is interesting because in contrast to mammals, fish are not particularly dependent upon food for their calcium. The major fraction of calcium required by the fish is taken up directly from the water via the gills (Verbost et al. 1994) and the uptake rate is largely independent of thevitamin D receptor (VDR), a member of the nuclear receptor superfamily. The VDR shows great sequence and structural resemblance with the subfamily that includes peroxisome flounder (Suzuki et al. 2000), zebrafish (NM130919), and common carp (AJ784084). In European eel, Anguilla anguilla, calcitriol administration in vivo increased serum phosphateparr, SW adapting smolts, and in SW adults, plasma |
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