CORRESPONDENCE Re: MLH1 − 93G>A Promoter
Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition t...
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| Format: | Text |
| Language: | English |
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.553.4167 http://jnci.oxfordjournals.org/content/99/19/1490.2.full.pdf |
| Summary: | Raptis et al. ( 1) propose an association be-tween the MLH1 − 93G>A polymorphism and colorectal cancers with high micro-satellite instability (MSI-H) status and sug-gest that this variant is a low-penetrance allele for colorectal cancer susceptibility. Although it is plausible that, in addition to highly penetrant truncating mutations, com-mon variants of DNA mismatch repair genes such as MLH1 may contribute to colorectal cancer susceptibility, demonstrating causality is not straightforward. In the study of Raptis et al. ( 1), case patients with colorectal cancer were ascer-tained from the Ontario and Newfoundland |
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