Chemistry Central Journal Poster presentation Molecular modeling studies of lipase-catalyzed β-lactam polymerization

• Main Authors: La Haller, Lw Schwab, K Loos, G Fels
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Published: 2009
• Subjects: Antarc*; Antarctica
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.429.7053; http://journal.chemistrycentral.com/content/pdf/1752-153X-3-S1-P57.pdf

© 2009 Baum et al; licensee BioMed Central Ltd. Enzymatic polymerization has emerged over the last 5 years as a field of considerable interest and commercial promise. The reaction proceeds with high regio-, enantio-, and chemoselectivity under relatively mild conditions. Enzymes have been used so far to synthesize polyesters, polysaccharides, polycarbonates, polyphenols, polyanilines, vinyl polymers, and poly-amino acids [1]. Particularly, lipase B of Candida antarctica immobilized on polyacrylic resin (Novozyme 435) has proven to be a very versatile catalyst and has successfully been used for the synthesis of polyesters from various substrates [2][3][4]. Little, however, has been reported on the enzyme catalyzed synthesis of polyamides [5]. While it has been shown that nylons can chemically be produced from the corresponding amino acids or by anionic