Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

Abstract: A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2...

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Bibliographic Details
Main Authors: Guangwei Wu, Aiqun Lin, Qianqun Gu, Tianjiao Zhu, Dehai Li
Other Authors: The Pennsylvania State University CiteSeerX Archives
Format: Text
Language:English
Published: 2013
Subjects:
chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp
Antarctic
Antarc*
Online Access:http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.376.2418
http://www.mdpi.com/1660-3397/11/4/1399/pdf?y=1
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Summary:Abstract: A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.

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