Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium
Defective trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis. In chloride-secreting epithelia, it is well established that CFTR localizes to intracellular organelles and to apical membranes. However, it is controversial whether s...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.322.6237 2023-05-15T18:51:07+02:00 Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium Rüdiger W. Lehrich Stephen G. Aller Paul Webster Christopher R. Marino John N. Forrest The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.6237 http://edoc.mdc-berlin.de/5681/1/5681oa.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.6237 http://edoc.mdc-berlin.de/5681/1/5681oa.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://edoc.mdc-berlin.de/5681/1/5681oa.pdf text ftciteseerx 2016-09-04T00:22:54Z Defective trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis. In chloride-secreting epithelia, it is well established that CFTR localizes to intracellular organelles and to apical membranes. However, it is controversial whether secretagogues regulate the trafficking of CFTR. To investigate whether acute hormonal stimulation of chloride secretion is coupled to the trafficking of CFTR, we used the intact shark rectal gland, a model tissue in which salt secretion is dynamically regulated and both chloride secretion and cellular CFTR immunofluorescence can be quantified in parallel. In rectal glands perfused under basal conditions without secretagogues, Cl � secretion was 151�65 �eq/h/g. Vasoactive intestinal peptide (VIP), forskolin, and genistein Text spiny dogfish Squalus acanthias Unknown |
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ftciteseerx |
language |
English |
description |
Defective trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis. In chloride-secreting epithelia, it is well established that CFTR localizes to intracellular organelles and to apical membranes. However, it is controversial whether secretagogues regulate the trafficking of CFTR. To investigate whether acute hormonal stimulation of chloride secretion is coupled to the trafficking of CFTR, we used the intact shark rectal gland, a model tissue in which salt secretion is dynamically regulated and both chloride secretion and cellular CFTR immunofluorescence can be quantified in parallel. In rectal glands perfused under basal conditions without secretagogues, Cl � secretion was 151�65 �eq/h/g. Vasoactive intestinal peptide (VIP), forskolin, and genistein |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Rüdiger W. Lehrich Stephen G. Aller Paul Webster Christopher R. Marino John N. Forrest |
spellingShingle |
Rüdiger W. Lehrich Stephen G. Aller Paul Webster Christopher R. Marino John N. Forrest Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium |
author_facet |
Rüdiger W. Lehrich Stephen G. Aller Paul Webster Christopher R. Marino John N. Forrest |
author_sort |
Rüdiger W. Lehrich |
title |
Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium |
title_short |
Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium |
title_full |
Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium |
title_fullStr |
Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium |
title_full_unstemmed |
Rapid Publication Vasoactive Intestinal Peptide, Forskolin, and Genistein Increase Apical CFTR Trafficking in the Rectal Gland of the Spiny Dogfish, Squalus acanthias Acute Regulation of CFTR Trafficking in an Intact Epithelium |
title_sort |
rapid publication vasoactive intestinal peptide, forskolin, and genistein increase apical cftr trafficking in the rectal gland of the spiny dogfish, squalus acanthias acute regulation of cftr trafficking in an intact epithelium |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.6237 http://edoc.mdc-berlin.de/5681/1/5681oa.pdf |
genre |
spiny dogfish Squalus acanthias |
genre_facet |
spiny dogfish Squalus acanthias |
op_source |
http://edoc.mdc-berlin.de/5681/1/5681oa.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.6237 http://edoc.mdc-berlin.de/5681/1/5681oa.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766244908504449024 |