cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64
Some cetaceans bioaccumulate substantial concentrations of planar halogenated aromatic hydrocarbons (PHAHs) in their tissues, but little is known about the effects of such burdens on cetacean health. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related PHAHs cause toxicity via activation of the ar...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.321.8226 2023-05-15T15:41:30+02:00 cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 Brenda A. Jensen Mark E. Hahn The Pennsylvania State University CiteSeerX Archives 2001 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.8226 http://toxsci.oxfordjournals.org/content/64/1/41.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.8226 http://toxsci.oxfordjournals.org/content/64/1/41.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://toxsci.oxfordjournals.org/content/64/1/41.full.pdf text 2001 ftciteseerx 2016-09-04T00:21:27Z Some cetaceans bioaccumulate substantial concentrations of planar halogenated aromatic hydrocarbons (PHAHs) in their tissues, but little is known about the effects of such burdens on cetacean health. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related PHAHs cause toxicity via activation of the aryl hydrocarbon receptor (AHR), a member of the bHLH-PAS family of transcription factors. Differences in AHR structure and function are known to contribute to species-specific differences in susceptibility to PHAH toxicity. To ascertain the potential for PHAH effects in a cetacean, we characterized an AHR from the beluga whale, Delphinapterus leucas. The 3.2 kb cDNA encodes an 845-amino acid protein with a predicted size of 95.5 kDa. Overall, the beluga AHR shares 85 % amino acid sequence identity with the human AHR and 75 % identity with the mouse AHR Ah b–1 allele. Beluga AHR protein synthesized in a rabbit reticulocyte lysate system Text Beluga Beluga whale Beluga* Delphinapterus leucas Unknown |
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ftciteseerx |
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English |
description |
Some cetaceans bioaccumulate substantial concentrations of planar halogenated aromatic hydrocarbons (PHAHs) in their tissues, but little is known about the effects of such burdens on cetacean health. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related PHAHs cause toxicity via activation of the aryl hydrocarbon receptor (AHR), a member of the bHLH-PAS family of transcription factors. Differences in AHR structure and function are known to contribute to species-specific differences in susceptibility to PHAH toxicity. To ascertain the potential for PHAH effects in a cetacean, we characterized an AHR from the beluga whale, Delphinapterus leucas. The 3.2 kb cDNA encodes an 845-amino acid protein with a predicted size of 95.5 kDa. Overall, the beluga AHR shares 85 % amino acid sequence identity with the human AHR and 75 % identity with the mouse AHR Ah b–1 allele. Beluga AHR protein synthesized in a rabbit reticulocyte lysate system |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Brenda A. Jensen Mark E. Hahn |
spellingShingle |
Brenda A. Jensen Mark E. Hahn cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 |
author_facet |
Brenda A. Jensen Mark E. Hahn |
author_sort |
Brenda A. Jensen |
title |
cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 |
title_short |
cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 |
title_full |
cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 |
title_fullStr |
cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 |
title_full_unstemmed |
cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas. Toxicol Sci 64 |
title_sort |
cdna cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, delphinapterus leucas. toxicol sci 64 |
publishDate |
2001 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.8226 http://toxsci.oxfordjournals.org/content/64/1/41.full.pdf |
genre |
Beluga Beluga whale Beluga* Delphinapterus leucas |
genre_facet |
Beluga Beluga whale Beluga* Delphinapterus leucas |
op_source |
http://toxsci.oxfordjournals.org/content/64/1/41.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.8226 http://toxsci.oxfordjournals.org/content/64/1/41.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766374393315852288 |