4th International Workshop on Clinical Pharmacology of HIV Therapy
• Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study? • Up to one third of patients receiving standard doses of NNRTIs may be being underdosed • Nelfinavir concentrations are significantly higher in HIV/HCV co-infected patients with cirr...
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| Format: | Text |
| Language: | English |
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2003
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| Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.202.201 http://www.i-base.org.uk/pdf/htbvol4/htb4-4may03.pdf |
| Summary: | • Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study? • Up to one third of patients receiving standard doses of NNRTIs may be being underdosed • Nelfinavir concentrations are significantly higher in HIV/HCV co-infected patients with cirrhosis • Less diarrhoea and bioequivalence with the new nelfinavir 625mg tablet • The potential for probenecid to have a serious interaction with HIV-1 protease inhibitors • PK studies reveal significant sex/gender differences • Pregnancy-related PK studies • New test to measure intracellular levels of nucleosides • Case studies for therapeutic drug monitoring (TDM) • Launch of guide to use of drug level monitoring |
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