N-acylation of ethanolamine using lipase: a chemoselective catalyst

Abstract The N-acylation of ethanolamine (2) with various fatty acids 1a-d and esters of fatty acids 1e-h using Candida antarctica B lipase (Novozym ® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, so...

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Bibliographic Details
Main Authors: Mazaahir Kidwai, Roona Poddar, Poonam Mothsra, Open Access
Other Authors: The Pennsylvania State University CiteSeerX Archives
Format: Text
Language:English
Published: 2009
Subjects:
Antarc*
Antarctica
Online Access:http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1052.9413
Description
Summary:Abstract The N-acylation of ethanolamine (2) with various fatty acids 1a-d and esters of fatty acids 1e-h using Candida antarctica B lipase (Novozym ® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.

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