Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster
MyD88 is a universal adapter protein for the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling pathway. Since invertebrates are believed to lack MyD88-independent pathways, MyD88 appears more critical in oyster TLR signaling pathway. In the Pacific oyster (Crassostrea gigas), two compl...
Published in: | Fish & Shellfish Immunology |
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/164485 2023-05-15T15:57:48+02:00 Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster Tang, Xueying Huang, Baoyu Lin, Siheng Wang, Wei Zhang, Guofan Li, Li 2020 http://ir.qdio.ac.cn/handle/337002/164484 http://ir.qdio.ac.cn/handle/337002/164485 https://doi.org/10.1016/j.fsi.2019.10.060 英语 eng ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD FISH & SHELLFISH IMMUNOLOGY http://ir.qdio.ac.cn/handle/337002/164484 http://ir.qdio.ac.cn/handle/337002/164485 doi:10.1016/j.fsi.2019.10.060 Crassostrea gigas Innate immunity MyD88 Functional diversity Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences 期刊论文 2020 ftchinacasciocas https://doi.org/10.1016/j.fsi.2019.10.060 2022-06-27T05:41:43Z MyD88 is a universal adapter protein for the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling pathway. Since invertebrates are believed to lack MyD88-independent pathways, MyD88 appears more critical in oyster TLR signaling pathway. In the Pacific oyster (Crassostrea gigas), two complete paralogues, named as CgMyD88-1 and CgMyD88-2, have been identified. In the current study, we indicated that CgMyD88-1 and CgMyD88-2 might act synergistically to increase the efficiency of immune signaling by activating NF-kappa B transcription factor. However, we found that upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid [poly (I:C)], CgMyD88-1 and CgMyD88-2 show differences in their response: CgMyD88-1 accumulated as large spots in the cytoplasm, while CgMyD88-2 assembled in the cytoplasm and in the membrane. Our results support the theory that expansion of these immune genes is associated with functional diversity. Report Crassostrea gigas Pacific oyster Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Pacific Fish & Shellfish Immunology 96 138 140 |
institution |
Open Polar |
collection |
Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
op_collection_id |
ftchinacasciocas |
language |
English |
topic |
Crassostrea gigas Innate immunity MyD88 Functional diversity Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences |
spellingShingle |
Crassostrea gigas Innate immunity MyD88 Functional diversity Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences Tang, Xueying Huang, Baoyu Lin, Siheng Wang, Wei Zhang, Guofan Li, Li Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster |
topic_facet |
Crassostrea gigas Innate immunity MyD88 Functional diversity Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences |
description |
MyD88 is a universal adapter protein for the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling pathway. Since invertebrates are believed to lack MyD88-independent pathways, MyD88 appears more critical in oyster TLR signaling pathway. In the Pacific oyster (Crassostrea gigas), two complete paralogues, named as CgMyD88-1 and CgMyD88-2, have been identified. In the current study, we indicated that CgMyD88-1 and CgMyD88-2 might act synergistically to increase the efficiency of immune signaling by activating NF-kappa B transcription factor. However, we found that upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid [poly (I:C)], CgMyD88-1 and CgMyD88-2 show differences in their response: CgMyD88-1 accumulated as large spots in the cytoplasm, while CgMyD88-2 assembled in the cytoplasm and in the membrane. Our results support the theory that expansion of these immune genes is associated with functional diversity. |
format |
Report |
author |
Tang, Xueying Huang, Baoyu Lin, Siheng Wang, Wei Zhang, Guofan Li, Li |
author_facet |
Tang, Xueying Huang, Baoyu Lin, Siheng Wang, Wei Zhang, Guofan Li, Li |
author_sort |
Tang, Xueying |
title |
Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster |
title_short |
Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster |
title_full |
Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster |
title_fullStr |
Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster |
title_full_unstemmed |
Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster |
title_sort |
functional relationship between cgmyd88-1 and cgmyd88-2 in the pacific oyster |
publisher |
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
publishDate |
2020 |
url |
http://ir.qdio.ac.cn/handle/337002/164484 http://ir.qdio.ac.cn/handle/337002/164485 https://doi.org/10.1016/j.fsi.2019.10.060 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
FISH & SHELLFISH IMMUNOLOGY http://ir.qdio.ac.cn/handle/337002/164484 http://ir.qdio.ac.cn/handle/337002/164485 doi:10.1016/j.fsi.2019.10.060 |
op_doi |
https://doi.org/10.1016/j.fsi.2019.10.060 |
container_title |
Fish & Shellfish Immunology |
container_volume |
96 |
container_start_page |
138 |
op_container_end_page |
140 |
_version_ |
1766393502967529472 |