The association between DNA methylation and exon expression in the Pacific oyster Crassostrea gigas

Background DNA methylation is one of the most important epigenetic modifications of eukaryotic genomes and is believed to play integral roles in diverse biological processes. Although DNA methylation has been well studied in mammals, data are limited in invertebrates, particularly Mollusca. The Paci...

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Bibliographic Details
Published in:PLOS ONE
Main Authors: Song, Kai, Li, Li, Zhang, Guofan
Format: Article in Journal/Newspaper
Language:English
Published: 2017
Subjects:
Pacific
Crassostrea gigas
Pacific oyster
Online Access:http://ir.qdio.ac.cn/handle/337002/143196
https://doi.org/10.1371/journal.pone.0185224
Description
Summary:Background DNA methylation is one of the most important epigenetic modifications of eukaryotic genomes and is believed to play integral roles in diverse biological processes. Although DNA methylation has been well studied in mammals, data are limited in invertebrates, particularly Mollusca. The Pacific oyster Crassostrea gigas is an emerging genetic model for functional analysis of DNA methylation in Mollusca. Recent studies have shown that there is a positive association between methylation status and gene expression in C. gigas; however, whether this association exists at the exon level remains to be determined.

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