Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer
Certain ciliates of the subclass Scuticociliatia (scuticociliates) are facultative parasites of fishes in which they cause a suite of diseases collectively termed scuticociliatosis. Hitherto, comparatively little was known about genetics and genomics of scuticociliates or the mechanism of scuticocil...
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ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/27278 2023-05-15T18:15:47+02:00 Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer Xiong, Jie Wang, Guangying Cheng, Jun Tian, Miao Pan, Xuming Warren, Alan Jiang, Chuanqi Yuan, Dongxia Miao, Wei 2015-10-21 http://ir.ihb.ac.cn/handle/342005/27278 https://doi.org/10.1038/srep15470 英语 eng SCIENTIFIC REPORTS http://ir.ihb.ac.cn/handle/342005/27278 doi:10.1038/srep15470 Science & Technology Science & Technology - Other Topics Multidisciplinary Sciences FLOUNDER PARALICHTHYS-OLIVACEUS TURBOT SCOPHTHALMUS-MAXIMUS PHOSPHOLIPASE-C URONEMA-MARINUM PHILASTERIDES-DICENTRARCHI RNA-SEQ PLASMODIUM-FALCIPARUM STAPHYLOCOCCUS-AUREUS PROTECTIVE IMMUNITY HEMOLYSIN-III Article 期刊论文 2015 ftchinacadsciihb https://doi.org/10.1038/srep15470 2019-08-30T00:03:55Z Certain ciliates of the subclass Scuticociliatia (scuticociliates) are facultative parasites of fishes in which they cause a suite of diseases collectively termed scuticociliatosis. Hitherto, comparatively little was known about genetics and genomics of scuticociliates or the mechanism of scuticociliatosis. In this study, a laboratory culture of the facultatively pathogenic scuticociliate Pseudocohnilembus persalinus was established and its genome sequenced, giving the first genome of a marine ciliate. Genome-wide horizontal gene transfer (HGT) analysis showed P. persalinus has acquired many unique prokaryote-derived genes that potentially contribute to the virulence of this organism, including cell adhesion, hemolysis and heme utilization genes. These findings give new insights into our understanding of the pathology of scuticociliates. Article in Journal/Newspaper Scophthalmus maximus Turbot Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Scientific Reports 5 1 |
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Open Polar |
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Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
Science & Technology Science & Technology - Other Topics Multidisciplinary Sciences FLOUNDER PARALICHTHYS-OLIVACEUS TURBOT SCOPHTHALMUS-MAXIMUS PHOSPHOLIPASE-C URONEMA-MARINUM PHILASTERIDES-DICENTRARCHI RNA-SEQ PLASMODIUM-FALCIPARUM STAPHYLOCOCCUS-AUREUS PROTECTIVE IMMUNITY HEMOLYSIN-III |
spellingShingle |
Science & Technology Science & Technology - Other Topics Multidisciplinary Sciences FLOUNDER PARALICHTHYS-OLIVACEUS TURBOT SCOPHTHALMUS-MAXIMUS PHOSPHOLIPASE-C URONEMA-MARINUM PHILASTERIDES-DICENTRARCHI RNA-SEQ PLASMODIUM-FALCIPARUM STAPHYLOCOCCUS-AUREUS PROTECTIVE IMMUNITY HEMOLYSIN-III Xiong, Jie Wang, Guangying Cheng, Jun Tian, Miao Pan, Xuming Warren, Alan Jiang, Chuanqi Yuan, Dongxia Miao, Wei Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
topic_facet |
Science & Technology Science & Technology - Other Topics Multidisciplinary Sciences FLOUNDER PARALICHTHYS-OLIVACEUS TURBOT SCOPHTHALMUS-MAXIMUS PHOSPHOLIPASE-C URONEMA-MARINUM PHILASTERIDES-DICENTRARCHI RNA-SEQ PLASMODIUM-FALCIPARUM STAPHYLOCOCCUS-AUREUS PROTECTIVE IMMUNITY HEMOLYSIN-III |
description |
Certain ciliates of the subclass Scuticociliatia (scuticociliates) are facultative parasites of fishes in which they cause a suite of diseases collectively termed scuticociliatosis. Hitherto, comparatively little was known about genetics and genomics of scuticociliates or the mechanism of scuticociliatosis. In this study, a laboratory culture of the facultatively pathogenic scuticociliate Pseudocohnilembus persalinus was established and its genome sequenced, giving the first genome of a marine ciliate. Genome-wide horizontal gene transfer (HGT) analysis showed P. persalinus has acquired many unique prokaryote-derived genes that potentially contribute to the virulence of this organism, including cell adhesion, hemolysis and heme utilization genes. These findings give new insights into our understanding of the pathology of scuticociliates. |
format |
Article in Journal/Newspaper |
author |
Xiong, Jie Wang, Guangying Cheng, Jun Tian, Miao Pan, Xuming Warren, Alan Jiang, Chuanqi Yuan, Dongxia Miao, Wei |
author_facet |
Xiong, Jie Wang, Guangying Cheng, Jun Tian, Miao Pan, Xuming Warren, Alan Jiang, Chuanqi Yuan, Dongxia Miao, Wei |
author_sort |
Xiong, Jie |
title |
Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
title_short |
Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
title_full |
Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
title_fullStr |
Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
title_full_unstemmed |
Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
title_sort |
genome of the facultative scuticociliatosis pathogen pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer |
publishDate |
2015 |
url |
http://ir.ihb.ac.cn/handle/342005/27278 https://doi.org/10.1038/srep15470 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_relation |
SCIENTIFIC REPORTS http://ir.ihb.ac.cn/handle/342005/27278 doi:10.1038/srep15470 |
op_doi |
https://doi.org/10.1038/srep15470 |
container_title |
Scientific Reports |
container_volume |
5 |
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1 |
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1766189002081173504 |