Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer

Certain ciliates of the subclass Scuticociliatia (scuticociliates) are facultative parasites of fishes in which they cause a suite of diseases collectively termed scuticociliatosis. Hitherto, comparatively little was known about genetics and genomics of scuticociliates or the mechanism of scuticocil...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Xiong, Jie, Wang, Guangying, Cheng, Jun, Tian, Miao, Pan, Xuming, Warren, Alan, Jiang, Chuanqi, Yuan, Dongxia, Miao, Wei
Format: Article in Journal/Newspaper
Language:English
Published: 2015
Subjects:
Science & Technology
Science & Technology - Other Topics
Multidisciplinary Sciences
FLOUNDER PARALICHTHYS-OLIVACEUS
TURBOT SCOPHTHALMUS-MAXIMUS
PHOSPHOLIPASE-C
URONEMA-MARINUM
PHILASTERIDES-DICENTRARCHI
RNA-SEQ
PLASMODIUM-FALCIPARUM
STAPHYLOCOCCUS-AUREUS
PROTECTIVE IMMUNITY
HEMOLYSIN-III
Scophthalmus maximus
Turbot
Online Access:http://ir.ihb.ac.cn/handle/342005/27278
https://doi.org/10.1038/srep15470
Description
Summary:Certain ciliates of the subclass Scuticociliatia (scuticociliates) are facultative parasites of fishes in which they cause a suite of diseases collectively termed scuticociliatosis. Hitherto, comparatively little was known about genetics and genomics of scuticociliates or the mechanism of scuticociliatosis. In this study, a laboratory culture of the facultatively pathogenic scuticociliate Pseudocohnilembus persalinus was established and its genome sequenced, giving the first genome of a marine ciliate. Genome-wide horizontal gene transfer (HGT) analysis showed P. persalinus has acquired many unique prokaryote-derived genes that potentially contribute to the virulence of this organism, including cell adhesion, hemolysis and heme utilization genes. These findings give new insights into our understanding of the pathology of scuticociliates.

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