Phenanthrene alters the electrical activity of atrial and ventricular myocytes of a polar fish, the Navaga cod.

From PubMed via Jisc Publications Router History: received 2020-08-22, revised 2021-03-18, accepted 2021-03-26 Publication status: ppublish Oil and gas exploration in the Arctic can result in the release of polycyclic aromatic hydrocarbons (PAHs) into relatively pristine environments. Following the...

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Bibliographic Details
Published in:Aquatic Toxicology
Main Authors: Abramochkin, Denis V, Kompella, Shiva N, Shiels, Holly A
Format: Article in Journal/Newspaper
Language:English
Published: 2021
Subjects:
Arctic
Cardiotoxicity
Eleginus nawaga
Heart
Petroleum pollution
White sea
White Sea
Norilsk
Navaga
norilsk
Online Access:http://hdl.handle.net/10034/624520
https://doi.org/10.1016/j.aquatox.2021.105823
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Summary:From PubMed via Jisc Publications Router History: received 2020-08-22, revised 2021-03-18, accepted 2021-03-26 Publication status: ppublish Oil and gas exploration in the Arctic can result in the release of polycyclic aromatic hydrocarbons (PAHs) into relatively pristine environments. Following the recent spill of approximately 17 500 tonnes of diesel fuel in Norilsk, Russia, May 2020, our study focussed on the effects of phenanthrene, a low molecular weight PAH found in diesel and crude oil, on the isolated atrial and ventricular myocytes from the heart of the polar teleost, the Navaga cod (Eleginus nawaga). Acute exposure to phenanthrene in navaga cardiomyocytes caused significant action potential (AP) prolongation, confirming the proarrhythmic effects of this pollutant. We show AP prolongation was due to potent inhibition of the main repolarising current, I , with an IC value of ~2 µM. We also show a potent inhibitory effect (~55%) of 1 µM phenanthrene on the transient I currents that protects the heart from early-after-depolarizations and arrhythmias. These data, along with more minor effects on inward sodium (I ) (~17% inhibition at 10 µM) and calcium (I ) (~17% inhibition at 30 µM) currents, and no effects on inward rectifier (I and I ) currents, demonstrate the cardiotoxic effects exerted by phenanthrene on the atrium and ventricle of navaga cod. Moreover, we report the first data that we are aware of on the impact of phenanthrene on atrial myocyte function in any fish species. [Abstract copyright: Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.]

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