Lipase-catalyzed enantioselective hydrolysis of methyl 2-fluoro-2-arylpropionates in water-saturated isooctane

• Published in: Journal of Molecular Catalysis B: Enzymatic
• Main Authors: Wang, Pei-Yun, Chen, Teh-Liang, Tsai, Shau-Wei, Cipiciani, Antonio, Bellezza, Francesca, Ruzziconi, Renzo
• Other Authors: Department of Chemical Engineering
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2006
• Subjects: lipases; enantioselective hydrolysis; methyl 2-fluoro-2-arylpropionates; naproxen methyl ester; Rugosa; antartic*
• Online Access: https://doi.org/10.1016/j.molcatb.2006.07.003; http://ir.lib.ncku.edu.tw/handle/987654321/81795

Lipases from Candida rugosa, Candida antartica B and Carica papaya are employed as the biocatalyst for the hydrolytic resolution of methyl 2-fluoro-2-arylpropionates in water-saturated isooctane, in which excellent to good enantioselectivity without the formation of byproducts is obtained for the pa...