Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress.
Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and oxidative stress response. Here, we show that neither...
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2023
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ftcdlib:oai:escholarship.org:ark:/13030/qt7ps901s4 2024-01-14T10:02:21+01:00 Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. Mittal, Pragya Sipani, Rashmi Pandiyan, Apuratha Sulthana, Shaheen Sinha, Anurag Hussain, Ashaq Ray, Malay Pavankumar, Theetha 2023-11-29 application/pdf https://escholarship.org/uc/item/7ps901s4 unknown eScholarship, University of California qt7ps901s4 https://escholarship.org/uc/item/7ps901s4 public Applied and Environmental Microbiology, vol 89, iss 11 DNA damage Pseudomonas syringae RNA degradation RNA degradosome RNase R oxidative stress Exoribonucleases Escherichia coli Antarctic Regions RNA Bacterial article 2023 ftcdlib 2023-12-18T19:08:43Z Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and oxidative stress response. Here, we show that neither the exoribonuclease function of RNase R nor its association with the RNA degradosome complex is essential for this function. Interestingly, in P. syringae Lz4W, hydrolytic RNase R exhibits physiological roles similar to phosphorolytic 3-5 exoribonuclease PNPase of E. coli. Our data suggest that during the course of evolution, mesophilic E. coli and psychrotrophic P. syringae have apparently swapped these exoribonucleases to adapt to their respective environmental growth conditions. Article in Journal/Newspaper Antarc* Antarctic University of California: eScholarship Antarctic |
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University of California: eScholarship |
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topic |
DNA damage Pseudomonas syringae RNA degradation RNA degradosome RNase R oxidative stress Exoribonucleases Escherichia coli Antarctic Regions RNA Bacterial |
spellingShingle |
DNA damage Pseudomonas syringae RNA degradation RNA degradosome RNase R oxidative stress Exoribonucleases Escherichia coli Antarctic Regions RNA Bacterial Mittal, Pragya Sipani, Rashmi Pandiyan, Apuratha Sulthana, Shaheen Sinha, Anurag Hussain, Ashaq Ray, Malay Pavankumar, Theetha Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. |
topic_facet |
DNA damage Pseudomonas syringae RNA degradation RNA degradosome RNase R oxidative stress Exoribonucleases Escherichia coli Antarctic Regions RNA Bacterial |
description |
Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and oxidative stress response. Here, we show that neither the exoribonuclease function of RNase R nor its association with the RNA degradosome complex is essential for this function. Interestingly, in P. syringae Lz4W, hydrolytic RNase R exhibits physiological roles similar to phosphorolytic 3-5 exoribonuclease PNPase of E. coli. Our data suggest that during the course of evolution, mesophilic E. coli and psychrotrophic P. syringae have apparently swapped these exoribonucleases to adapt to their respective environmental growth conditions. |
format |
Article in Journal/Newspaper |
author |
Mittal, Pragya Sipani, Rashmi Pandiyan, Apuratha Sulthana, Shaheen Sinha, Anurag Hussain, Ashaq Ray, Malay Pavankumar, Theetha |
author_facet |
Mittal, Pragya Sipani, Rashmi Pandiyan, Apuratha Sulthana, Shaheen Sinha, Anurag Hussain, Ashaq Ray, Malay Pavankumar, Theetha |
author_sort |
Mittal, Pragya |
title |
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. |
title_short |
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. |
title_full |
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. |
title_fullStr |
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. |
title_full_unstemmed |
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. |
title_sort |
exoribonuclease rnase r protects antarctic pseudomonas syringae lz4w from dna damage and oxidative stress. |
publisher |
eScholarship, University of California |
publishDate |
2023 |
url |
https://escholarship.org/uc/item/7ps901s4 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Applied and Environmental Microbiology, vol 89, iss 11 |
op_relation |
qt7ps901s4 https://escholarship.org/uc/item/7ps901s4 |
op_rights |
public |
_version_ |
1788057327820079104 |