Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress.

Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and oxidative stress response. Here, we show that neither...

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Bibliographic Details
Main Authors: Mittal, Pragya, Sipani, Rashmi, Pandiyan, Apuratha, Sulthana, Shaheen, Sinha, Anurag, Hussain, Ashaq, Ray, Malay, Pavankumar, Theetha
Format: Article in Journal/Newspaper
Language:unknown
Published: eScholarship, University of California 2023
Subjects:
DNA damage
Pseudomonas syringae
RNA degradation
RNA degradosome
RNase R
oxidative stress
Exoribonucleases
Escherichia coli
Antarctic Regions
RNA
Bacterial
Antarctic
Antarc*
Online Access:https://escholarship.org/uc/item/7ps901s4
Description
Summary:Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and oxidative stress response. Here, we show that neither the exoribonuclease function of RNase R nor its association with the RNA degradosome complex is essential for this function. Interestingly, in P. syringae Lz4W, hydrolytic RNase R exhibits physiological roles similar to phosphorolytic 3-5 exoribonuclease PNPase of E. coli. Our data suggest that during the course of evolution, mesophilic E. coli and psychrotrophic P. syringae have apparently swapped these exoribonucleases to adapt to their respective environmental growth conditions.

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