Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion

Gene variants that influence human biology today reflect thousands of years of evolution. Genetic effects on infant health are a major point of selective pressure, given that childhood survival is essential to evolutionary success. Knowledge of this evolutionary history can have implications for pae...

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Bibliographic Details
Main Authors: Hlusko, Leslea J, McNelis, Madeline G
Format: Article in Journal/Newspaper
Language:unknown
Published: eScholarship, University of California 2022
Subjects:
Paediatrics
Biomedical and Clinical Sciences
Pediatric
Genetics
Underpinning research
1.1 Normal biological development and functioning
Child
Fatty Acid Desaturases
Fatty Acids
Female
Humans
Infant
Inflammation
Sunlight
Ultraviolet Rays
Paediatrics and Reproductive Medicine
Pediatrics
Arctic
Online Access:https://escholarship.org/uc/item/4bs257td
Description
Summary:Gene variants that influence human biology today reflect thousands of years of evolution. Genetic effects on infant health are a major point of selective pressure, given that childhood survival is essential to evolutionary success. Knowledge of this evolutionary history can have implications for paediatric research. CONCLUSION: An episode of human adaptation to the extremely low ultraviolet radiation environment of the Arctic 20,000years ago implicates the Ectodysplasin A Receptor (EDAR) and the Fatty Acid Desaturases (FADS) in human lactation and epithelial inflammation.

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