Experimental host-induced selection in Schistosoma mansoni strains from Guadeloupe and comparison with natural observations

International audience Allelic frequency variation at the malate dehydrogenase (E.C.1.1.1.37) polymorphic locus (Mdh-1) was analysed during several successive generations in four strains of Schistosoma mansoni from Guadeloupe, maintained experimentally on mice. A rapid evolution of the frequency of...

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Bibliographic Details
Published in:Heredity
Main Authors: Bremond, P., Pasteur, Nicole, Combes, Claude, Renaud, François, Theron, André
Other Authors: Parasitologie fonctionnelle et évolutive 2003-2006 (PFE), Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement IRD : UR226, Génétique et évolution des maladies infectieuses (GEMI), Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD France-Sud )
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 1993
Subjects:
HOST SELECTION
PARASITE
RANDOM DRIFT
RATTUS RATTUS
SCHISTOSOMA MANSONI
ENZYME POLYMORPHISM
WEST-INDIES
POPULATIONS
RODHAINI
ENZYMATIC POLYMORPHISM
[SDV.GEN]Life Sciences [q-bio]/Genetics
Rattus rattus
Online Access:https://hal.archives-ouvertes.fr/halsde-00201339
https://doi.org/10.1038/hdy.1993.5
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Summary:International audience Allelic frequency variation at the malate dehydrogenase (E.C.1.1.1.37) polymorphic locus (Mdh-1) was analysed during several successive generations in four strains of Schistosoma mansoni from Guadeloupe, maintained experimentally on mice. A rapid evolution of the frequency of the Mdh-1a allele is interpreted as being the result of an interaction between experimental drift and selection induced by the murine laboratory host. These experimental results are compared to the genetic structures observed among the corresponding natural populations of S. mansoni in Guadeloupe (West Indies). They strengthen the hypothesis of a natural host-induced selection by the murine host (Rattus rattus), which, in Guadeloupe, plays the role of host reservoir for this human schistosome.

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