Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome

Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adapt...

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Bibliographic Details
Published in:Science Advances
Main Authors: Gawra, Janan, Valdivieso, Alejandro, Roux, Fabrice, Laporte, Martin, de Lorgeril, Julien, Gueguen, Yannick, Saccas, Mathilde, Escoubas, Jean-Michel, Montagnani, Caroline, Destoumieux-Garzόn, Delphine, Lagarde, Franck, Leroy, Marc, Haffner, Philippe, Petton, Bruno, Cosseau, Céline, Morga, Benjamin, Dégremont, Lionel, Mitta, Guillaume, Grunau, Christoph, Vidal-Dupiol, Jeremie
Other Authors: Laboratoire des Interactions Plantes Microbes Environnement (LIPME), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Perpignan Via Domitia (UPVD)
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2023
Subjects:
[SDE]Environmental Sciences
Pacific
Pacific oyster
Online Access:https://hal.science/hal-04251055
https://doi.org/10.1126/sciadv.adh8990
Description
Summary:Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adaptation may arise through genetics and epigenetics. In this study, we used (epi)genome-wide association mapping to show that oysters differentially exposed to POMS displayed genetic and epigenetic signatures of selection. Consistent with higher resistance to POMS, the genes targeted included many genes in several pathways related to immunity. By combining correlation, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of phenotypic variation was explained by interactions between the genetic and epigenetic information, ~14% by the genome, and up to 25% by the epigenome alone. Similar to genetically based adaptation, epigenetic mechanisms notably governing immune responses can contribute substantially to the rapid adaptation of hosts to emerging infectious diseases.

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