Antarctic krill oil high internal phase Pickering emulsion stabilized by bamboo protein gels and the anti-inflammatory effect in vitro and in vivo

International audience This study aims to introduce a high internal phase Pickering emulsion (HIPPE) stabilized by bamboo fungus protein gel particles (BGPs), incorporating Antarctic krill oil (KO), as a new delivery formulation to enrich the application of KO. The appropriate proportion of KO (2:8)...

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Bibliographic Details
Published in:Journal of Functional Foods
Main Authors: Zhang, Minghao, Zhu, Jinrui, Zhou, Li, Kan, Jianquan, Zhao, Minjie, Huang, Rong, Liu, Jikai, Marchioni, Eric
Other Authors: South-Central MinZu University (SCUEC), Southwest University Chongqing, Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2022
Subjects:
Fungus
Delivery system
Preparation
Pickering stabilizer
Anti-inflammatory
Ulcerative colitis
[SDV.IDA]Life Sciences [q-bio]/Food engineering
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
Antarctic
Antarc*
Antarctic Krill
Online Access:https://hal.science/hal-03685322
https://hal.science/hal-03685322/document
https://hal.science/hal-03685322/file/1-s2.0-S1756464622002043-main.pdf
https://doi.org/10.1016/j.jff.2022.105134
Description
Summary:International audience This study aims to introduce a high internal phase Pickering emulsion (HIPPE) stabilized by bamboo fungus protein gel particles (BGPs), incorporating Antarctic krill oil (KO), as a new delivery formulation to enrich the application of KO. The appropriate proportion of KO (2:8) contributed to HIPPE stabilization (φ = 80%). At pH 11, strong electrostatic interaction tended to produce KO-HIPPE with small droplet and homogeneous size (1.5 μm). BGPs dosage either under (0.5%) or high (2.0%) was prone to the destabilization of KO-HIPPE. In vitro studies indicated that KO-HIPPE had no effect on cell viability and suggested the safety and anti-inflammatory effect. In vivo studies showed that KO-HIPPE treatment could improve the clinical symptoms, suppress the overexpression of the pro-inflammatory cytokines (TNF-α and IL-6) and protect the intestinal barrier with function. The findings demonstrated that the HIPPE stabilized on BGPs had excellent loading efficiency of KO and good security, stability and functional activity.

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