Telomere length is heritable and genetically correlated with lifespan in a wild bird

International audience Telomeres are protective caps at the end of eukaryotic chromosomes that shorten with age and in response to stressful or resource-demanding conditions. Their length predicts individual health and lifespan across a wide range of animals, but whether the observed positive associ...

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Bibliographic Details
Published in:Molecular Ecology
Main Authors: Vedder, Oscar, Moiron, Maria, Bichet, Coraline, Bauch, Christina, Verhulst, Simon, Becker, Peter, Bouwhuis, Sandra
Other Authors: Institute of Avian Research, Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groningen Institute for Evolutionary Life Sciences Groningen (GELIFES), University of Groningen Groningen
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2022
Subjects:
ageing
biomarker
birds
heritability
senescence
telomeres
[SDE]Environmental Sciences
Common tern
Sterna hirundo
Online Access:https://hal.science/hal-03576754
https://doi.org/10.1111/mec.15807
Description
Summary:International audience Telomeres are protective caps at the end of eukaryotic chromosomes that shorten with age and in response to stressful or resource-demanding conditions. Their length predicts individual health and lifespan across a wide range of animals, but whether the observed positive association between telomere length and lifespan is environmentally induced, or set at conception due to a shared genetic basis, has not been tested in wild animals. We applied quantitative genetic “animal models” to longitudinal telomere measurements collected over a 10-year period from individuals of a wild seabird (common tern; Sterna hirundo) with known pedigree. We found no variation in telomere shortening with age among individuals at the phenotypic and genetic level, and only a small permanent environmental effect on adult telomere length. Instead, we found telomere length to be highly heritable and strongly positively genetically correlated with lifespan. Such heritable differences between individuals that are set at conception may present a hitherto underappreciated component of variation in somatic state.

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