A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance
International audience Anthrax is an important disease caused by the bacterium Bacillus anthracis affecting both domestic and wild animals at the wildlife/livestock interface, defined here as a physical space in which wild and domestic species overlap in range and potentially interact. In endemic re...
Published in: | Epidemiology and Infection |
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ftccsdartic:oai:HAL:hal-02622855v1 2023-05-15T15:51:06+02:00 A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance Mukarati, N.L. Ndumnego, O. van Heerden, H. Ndhlovu, D. N. Matope, G. Caron, Alexandre De Garine-Wichatitsky, M. Pfukenyi, D. M. University of Zimbabwe (UZ) University of Pretoria South Africa Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) Faculdade de Veterinária Universidade Federal do Ceará = Federal University of Ceará (UFC) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) Kasetsart University (KU) 2018 https://hal.inrae.fr/hal-02622855 https://doi.org/10.1017/S0950268818001577 en eng HAL CCSD Cambridge University Press (CUP) info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268818001577 info:eu-repo/semantics/altIdentifier/pmid/29898801 hal-02622855 https://hal.inrae.fr/hal-02622855 doi:10.1017/S0950268818001577 PRODINRA: 455486 PUBMED: 29898801 WOS: 000441862700006 ISSN: 0950-2688 EISSN: 1469-4409 Epidemiology and Infection https://hal.inrae.fr/hal-02622855 Epidemiology and Infection, Cambridge University Press (CUP), 2018, 146 (12), pp.1526-1532. ⟨10.1017/S0950268818001577⟩ Anthrax domestic dogs wildlife/livestock interface Zimbabwe seroprevalence [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2018 ftccsdartic https://doi.org/10.1017/S0950268818001577 2021-11-07T01:05:41Z International audience Anthrax is an important disease caused by the bacterium Bacillus anthracis affecting both domestic and wild animals at the wildlife/livestock interface, defined here as a physical space in which wild and domestic species overlap in range and potentially interact. In endemic regions, sporadic anthrax outbreaks occur, causing significant deaths of both wildlife and livestock and sporadically, humans. However, it may also occur as isolated outbreaks with a few animals affected. Such isolated anthrax outbreaks maybe missed. High seroprevalence among carnivores suggests either regular non-fatal exposure to the pathogen circulating in a given environment, or contact with missed cases through consumption of anthrax carcases. To investigate the relevance of this potential indicator, a cross-sectional study was conducted to determine anthrax seroprevalence in domestic dogs (Canis lupus familiaris) from selected interface and non-interface areas of Zimbabwe with known history of anthrax outbreaks. Based on past anthrax outbreaks in the respective areas, the sites were further classified as high or low risk areas for anthrax outbreaks. Sera were collected from domestic dogs (n = 186) and tested for antibodies against B. anthracis protective antigens (PA) using an ELISA test. The overall seroprevalence was 51.6% (96/186; 95% CI 44.2-59.0). Sites from the non-interface areas recorded a significantly (P < 0.001) higher (72.1%) anthrax seroprevalence compared with those from the wildlife -livestock interface (41.5%). The results demonstrated a strong association (chi(2) = 14.3; OR = 3.2, 1.6 < OR < 6.2, P < 0.001) between anthrax seropositivity and interface type. Low-risk sites (42.5%) had a significantly (P = 0.044) lower seroprevalence compared with high-risk sites (58.5%) but still demonstrated high seroprevalence for areas where anthrax was last reported more than 20 years back. Dogs from Tsholotsho South were more than 90-times (OR = 96.5, 13.5 < OR < 690.8) more likely to be ... Article in Journal/Newspaper Canis lupus Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Epidemiology and Infection 146 12 1526 1532 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Anthrax domestic dogs wildlife/livestock interface Zimbabwe seroprevalence [SDV]Life Sciences [q-bio] |
spellingShingle |
Anthrax domestic dogs wildlife/livestock interface Zimbabwe seroprevalence [SDV]Life Sciences [q-bio] Mukarati, N.L. Ndumnego, O. van Heerden, H. Ndhlovu, D. N. Matope, G. Caron, Alexandre De Garine-Wichatitsky, M. Pfukenyi, D. M. A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance |
topic_facet |
Anthrax domestic dogs wildlife/livestock interface Zimbabwe seroprevalence [SDV]Life Sciences [q-bio] |
description |
International audience Anthrax is an important disease caused by the bacterium Bacillus anthracis affecting both domestic and wild animals at the wildlife/livestock interface, defined here as a physical space in which wild and domestic species overlap in range and potentially interact. In endemic regions, sporadic anthrax outbreaks occur, causing significant deaths of both wildlife and livestock and sporadically, humans. However, it may also occur as isolated outbreaks with a few animals affected. Such isolated anthrax outbreaks maybe missed. High seroprevalence among carnivores suggests either regular non-fatal exposure to the pathogen circulating in a given environment, or contact with missed cases through consumption of anthrax carcases. To investigate the relevance of this potential indicator, a cross-sectional study was conducted to determine anthrax seroprevalence in domestic dogs (Canis lupus familiaris) from selected interface and non-interface areas of Zimbabwe with known history of anthrax outbreaks. Based on past anthrax outbreaks in the respective areas, the sites were further classified as high or low risk areas for anthrax outbreaks. Sera were collected from domestic dogs (n = 186) and tested for antibodies against B. anthracis protective antigens (PA) using an ELISA test. The overall seroprevalence was 51.6% (96/186; 95% CI 44.2-59.0). Sites from the non-interface areas recorded a significantly (P < 0.001) higher (72.1%) anthrax seroprevalence compared with those from the wildlife -livestock interface (41.5%). The results demonstrated a strong association (chi(2) = 14.3; OR = 3.2, 1.6 < OR < 6.2, P < 0.001) between anthrax seropositivity and interface type. Low-risk sites (42.5%) had a significantly (P = 0.044) lower seroprevalence compared with high-risk sites (58.5%) but still demonstrated high seroprevalence for areas where anthrax was last reported more than 20 years back. Dogs from Tsholotsho South were more than 90-times (OR = 96.5, 13.5 < OR < 690.8) more likely to be ... |
author2 |
University of Zimbabwe (UZ) University of Pretoria South Africa Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) Faculdade de Veterinária Universidade Federal do Ceará = Federal University of Ceará (UFC) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) Kasetsart University (KU) |
format |
Article in Journal/Newspaper |
author |
Mukarati, N.L. Ndumnego, O. van Heerden, H. Ndhlovu, D. N. Matope, G. Caron, Alexandre De Garine-Wichatitsky, M. Pfukenyi, D. M. |
author_facet |
Mukarati, N.L. Ndumnego, O. van Heerden, H. Ndhlovu, D. N. Matope, G. Caron, Alexandre De Garine-Wichatitsky, M. Pfukenyi, D. M. |
author_sort |
Mukarati, N.L. |
title |
A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance |
title_short |
A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance |
title_full |
A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance |
title_fullStr |
A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance |
title_full_unstemmed |
A serological survey of anthrax in domestic dogs in Zimbabwe: a potential tool for anthrax surveillance |
title_sort |
serological survey of anthrax in domestic dogs in zimbabwe: a potential tool for anthrax surveillance |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://hal.inrae.fr/hal-02622855 https://doi.org/10.1017/S0950268818001577 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
ISSN: 0950-2688 EISSN: 1469-4409 Epidemiology and Infection https://hal.inrae.fr/hal-02622855 Epidemiology and Infection, Cambridge University Press (CUP), 2018, 146 (12), pp.1526-1532. ⟨10.1017/S0950268818001577⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268818001577 info:eu-repo/semantics/altIdentifier/pmid/29898801 hal-02622855 https://hal.inrae.fr/hal-02622855 doi:10.1017/S0950268818001577 PRODINRA: 455486 PUBMED: 29898801 WOS: 000441862700006 |
op_doi |
https://doi.org/10.1017/S0950268818001577 |
container_title |
Epidemiology and Infection |
container_volume |
146 |
container_issue |
12 |
container_start_page |
1526 |
op_container_end_page |
1532 |
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1766386163613958144 |