Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales

• Published in: BMC Evolutionary Biology
• Main Authors: Springer, Mark, Emerling, Christopher, Gatesy, John, Randall, Jason, Collin, Matthew, Hecker, Nikolai, Hiller, Michael, Delsuc, Frédéric
• Other Authors: Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS), Institute of Cellular Medicine Newcastle, Newcastle University Newcastle
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2019
• Subjects: [SDE.BE]Environmental Sciences/Biodiversity and Ecology; [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology; [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]; [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry; Molecular Biology/Genomics [q-bio.GN]; baleen whales; toothed whales
• Online Access: https://hal.archives-ouvertes.fr/hal-02322063; https://hal.archives-ouvertes.fr/hal-02322063/document; https://hal.archives-ouvertes.fr/hal-02322063/file/Springer-BMCEvolBiol-2019.pdf; https://doi.org/10.1186/s12862-019-1359-6

International audience Background: The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic functions that are unrelated to teeth. Here, we leverage the power of natural selection to test competing hypotheses that ODAM is tooth-specific versus pleiotropic. Specifically, we compiled and screened complete protein-coding sequences, plus sequences for flanking intronic regions, for ODAM in 165 placental mammals to determine if this gene contains inactivating mutations in lineages that either lack teeth (baleen whales, pangolins, anteaters) or lack enamel on their teeth (aardvarks, sloths, armadillos), as would be expected if the only essential functions of ODAM are related to tooth development and the adhesion of the gingival junctional epithelium to the enamel tooth surface.