Genome-wide asociation analysis identifies three psoriasis susceptibility loci

• Main Authors: Stuart, P.E., Nair, R.P., Elinghaus, E., Ding, J., Tejasvi, T., Gudjonson, J.E., Li, Y., Weidinger, S., Eberlein, B., Gieger, C., Wichman, H.E., Kunz, M., Ike, R., Krueger, G.G., Bowcock, A.M., Mrowietz, U., Lim, H.W., Vorhes, J.J., Abecasis, G.R., Weichenthal, M., Franke, A., Rahman, P., Gladman, D.D., Elder, J.T.
• Other Authors: Gillings School of Global Public Health, Department of Biostatistics
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2010
• Subjects: Germany; Arthritis; Psoriatic; Ontario; Newfoundland and Labrador; Humans; Psoriasis; Case-Control Studies; Proteasome Endopeptidase Complex; I-kappa B Proteins; Polymorphism; Single Nucleotide; Nitric Oxide Synthase Type II; Genotype; DNA-Binding Proteins; Genome-Wide Association Study; F-Box Proteins; Genetic Predisposition to Disease; Michigan; Newfoundland
• Online Access: https://doi.org/10.17615/c1qn-1p61; https://cdr.lib.unc.edu/downloads/8c97m1139?file=thumbnail; https://cdr.lib.unc.edu/downloads/8c97m1139

We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).