Genome-wide asociation analysis identifies three psoriasis susceptibility loci

We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,0...

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Bibliographic Details
Main Authors: Stuart, P.E., Nair, R.P., Elinghaus, E., Ding, J., Tejasvi, T., Gudjonson, J.E., Li, Y., Weidinger, S., Eberlein, B., Gieger, C., Wichman, H.E., Kunz, M., Ike, R., Krueger, G.G., Bowcock, A.M., Mrowietz, U., Lim, H.W., Vorhes, J.J., Abecasis, G.R., Weichenthal, M., Franke, A., Rahman, P., Gladman, D.D., Elder, J.T.
Other Authors: Gillings School of Global Public Health, Department of Biostatistics
Format: Article in Journal/Newspaper
Language:English
Published: 2010
Subjects:
Germany
Arthritis
Psoriatic
Ontario
Newfoundland and Labrador
Humans
Psoriasis
Case-Control Studies
Proteasome Endopeptidase Complex
I-kappa B Proteins
Polymorphism
Single Nucleotide
Nitric Oxide Synthase Type II
Genotype
DNA-Binding Proteins
Genome-Wide Association Study
F-Box Proteins
Genetic Predisposition to Disease
Michigan
Newfoundland
Online Access:https://doi.org/10.17615/c1qn-1p61
https://cdr.lib.unc.edu/downloads/8c97m1139?file=thumbnail
https://cdr.lib.unc.edu/downloads/8c97m1139
Description
Summary:We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).

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