Lipase-Mediated Enzymatic Catalysis For The Synthesis of New Chiral Polymers

Immobilized lipase B from Candida antarctica (N435) was investigated as a potential biocatalyst to generate silicone-based chiral polymers from monomers derived from the enzymatic dihydroxylation of bromobenzene. Several conditions and parameters have been investigated for this purpose and lipase tr...

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Bibliographic Details
Main Author: Naoum, Ravi
Other Authors: Centre for Biotechnology
Format: Thesis
Language:English
Published: Brock University 2015
Subjects:
Biocatalysis
Chiral polymers
Silicones
N435
Toluene dioxygenase
Antarc*
Antarctica
Online Access:http://hdl.handle.net/10464/5984
Description
Summary:Immobilized lipase B from Candida antarctica (N435) was investigated as a potential biocatalyst to generate silicone-based chiral polymers from monomers derived from the enzymatic dihydroxylation of bromobenzene. Several conditions and parameters have been investigated for this purpose and lipase transesterification preference to each of the free secondary alcohols in the chiral monomers was documented. The N435 was challenged with a series of substrates where the free alcohol moieties were systematically protected in order to study the substrate preference(s) for the transesterification reactions.

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