Forward Genetic Screen to Identify Novel Genes Involved in NHEJ DNA Repair
DNA contains all the information a cell needs to grow, divide, differentiate, and survive. It also dictates how and when a cell should die. DNA damage (particularly double strand breaks i.e. DSBs) may lead to cell death and/or disease. To circumvent DNA breaks, cells use various DNA repair mechanism...
| Main Authors: | , |
|---|---|
| Format: | Text |
| Language: | unknown |
| Published: |
BYU ScholarsArchive
2018
|
| Subjects: | |
| Online Access: | https://scholarsarchive.byu.edu/jur/vol2018/iss1/172 https://scholarsarchive.byu.edu/context/jur/article/1374/viewcontent/auto_convert.pdf |
| Summary: | DNA contains all the information a cell needs to grow, divide, differentiate, and survive. It also dictates how and when a cell should die. DNA damage (particularly double strand breaks i.e. DSBs) may lead to cell death and/or disease. To circumvent DNA breaks, cells use various DNA repair mechanisms including non-homologous end joining (NHEJ). My ORCA research project focused on identifying novel genes involved in NHEJ. I did this by performing a forward genetic screen (FGS) that tested every known gene in the genome for involvement in NHEJ. |
|---|