EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA)
A 14-yr- old, male harbor seal (Phoca vitulina) presented with depression, anorexia, and weight loss. Clinical examination revealed no specific abnormalities. Diagnostic imaging displayed an enlarged mass in the dorso-cranial abdomen. The animal was euthanized due to progressive worsening of symptom...
Published in: | Journal of Zoo and Wildlife Medicine |
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American Association of Zoo Veterinarians
2017
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ftbioone:10.1638/20160221R.1 2023-07-30T04:03:59+02:00 EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) Sara Malberg Henrike Alma Gregersen Manfred Henrich Christiane Herden Sara Malberg Henrike Alma Gregersen Manfred Henrich Christiane Herden world 2017-06-01 text/HTML https://doi.org/10.1638/20160221R.1 en eng American Association of Zoo Veterinarians doi:10.1638/20160221R.1 All rights reserved. https://doi.org/10.1638/20160221R.1 Text 2017 ftbioone https://doi.org/10.1638/20160221R.1 2023-07-09T10:51:57Z A 14-yr- old, male harbor seal (Phoca vitulina) presented with depression, anorexia, and weight loss. Clinical examination revealed no specific abnormalities. Diagnostic imaging displayed an enlarged mass in the dorso-cranial abdomen. The animal was euthanized due to progressive worsening of symptoms. Grossly, severe emaciation and a massive enlargement of one mesenteric lymph node were found. Microscopically, a neoplastic round cell population with morphologic characteristics of mature lymphocytes infiltrated the mesenteric lymph node as well as the jejunal mucosa and exhibited a marked invasion of the mucosal epithelial layer. Immunohistochemically, the majority of cells expressed CD3, but not CD79α, indicating a T-cell origin of the tumor cells. Microscopic as well as immunohistochemical findings enabled the diagnosis of an epitheliotropic intestinal T-cell lymphoma, a neoplasm that has yet not been described in a harbor seal. Text harbor seal Phoca vitulina BioOne Online Journals Journal of Zoo and Wildlife Medicine 48 2 568 572 |
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BioOne Online Journals |
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ftbioone |
language |
English |
description |
A 14-yr- old, male harbor seal (Phoca vitulina) presented with depression, anorexia, and weight loss. Clinical examination revealed no specific abnormalities. Diagnostic imaging displayed an enlarged mass in the dorso-cranial abdomen. The animal was euthanized due to progressive worsening of symptoms. Grossly, severe emaciation and a massive enlargement of one mesenteric lymph node were found. Microscopically, a neoplastic round cell population with morphologic characteristics of mature lymphocytes infiltrated the mesenteric lymph node as well as the jejunal mucosa and exhibited a marked invasion of the mucosal epithelial layer. Immunohistochemically, the majority of cells expressed CD3, but not CD79α, indicating a T-cell origin of the tumor cells. Microscopic as well as immunohistochemical findings enabled the diagnosis of an epitheliotropic intestinal T-cell lymphoma, a neoplasm that has yet not been described in a harbor seal. |
author2 |
Sara Malberg Henrike Alma Gregersen Manfred Henrich Christiane Herden |
format |
Text |
author |
Sara Malberg Henrike Alma Gregersen Manfred Henrich Christiane Herden |
spellingShingle |
Sara Malberg Henrike Alma Gregersen Manfred Henrich Christiane Herden EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) |
author_facet |
Sara Malberg Henrike Alma Gregersen Manfred Henrich Christiane Herden |
author_sort |
Sara Malberg |
title |
EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) |
title_short |
EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) |
title_full |
EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) |
title_fullStr |
EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) |
title_full_unstemmed |
EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA) |
title_sort |
epitheliotropic intestinal t-cell lymphoma in a harbor seal (phoca vitulina) |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2017 |
url |
https://doi.org/10.1638/20160221R.1 |
op_coverage |
world |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_source |
https://doi.org/10.1638/20160221R.1 |
op_relation |
doi:10.1638/20160221R.1 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/20160221R.1 |
container_title |
Journal of Zoo and Wildlife Medicine |
container_volume |
48 |
container_issue |
2 |
container_start_page |
568 |
op_container_end_page |
572 |
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1772815146628939776 |