CO2 induced pHi changes in the brain of polar fish: a TauCEST application

Chemical exchange saturation transfer from taurine to water (TauCEST) is primarily detectable in the low temperature range. Since, TauCEST asymmetry is bijective in the physiological pH-range (6.8-7.5), TauCEST is a potential candidate for in vivo studies on brain of polar fish. The specificity of T...

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Bibliographic Details
Main Authors: Wermter, Felizitas C., Maus, Bastian, Pörtner, Hans-Otto, Dreher, Wolfgang, Bock, Christian
Format: Conference Object
Language:unknown
Published: 2018
Subjects:
polar cod
Online Access:https://epic.awi.de/id/eprint/51195/
https://epic.awi.de/id/eprint/51195/1/Paris.pdf
https://hdl.handle.net/10013/epic.8639f652-7b00-461d-be8e-6343266f5877
https://hdl.handle.net/
Description
Summary:Chemical exchange saturation transfer from taurine to water (TauCEST) is primarily detectable in the low temperature range. Since, TauCEST asymmetry is bijective in the physiological pH-range (6.8-7.5), TauCEST is a potential candidate for in vivo studies on brain of polar fish. The specificity of TauCEST MRI on the brain of polar cod at 1.5°C shows a taurine contribution of 65%. TauCEST in brain of polar cod significantly increased under elevated CO2 concentrations by about 1.34%-3.17% in comparison to control, reflecting pHi changes since localized 1H NMR spectra show no significant changes in metabolite concentration for the different treatments.

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