Differential Expression of Novel Metabolic and Immunological Biomarkers in Oysters Challenged With a Virulent Strain of OsHV-1

Early lifestages of the Pacific oyster (Crassostrea gigas) are highly susceptible to infection by OsHV-1 μVar, but little information exists regarding metabolic or pathophysiological responses of larval hosts. Using a metabolomics approach, we identified a range of metabolic and immunological respon...

Full description

Bibliographic Details
Published in:Developmental & Comparative Immunology
Main Authors: Young, T, Kesarcodi-Watson, A, Alfaro, AC, Merien, F, Nguyen, TV, Mae, H, Le, DV, Villas-Bôas, S
Format: Article in Journal/Newspaper
Language:unknown
Published: Elsevier 2017
Subjects:
Aquaculture
Crassostrea gigas
Larvae
Metabolism
Metabolomics
Ostreid herpesvirus
Pacific
Pacific oyster
Online Access:https://hdl.handle.net/10292/10722
https://doi.org/10.1016/j.dci.2017.03.025
Description
Summary:Early lifestages of the Pacific oyster (Crassostrea gigas) are highly susceptible to infection by OsHV-1 μVar, but little information exists regarding metabolic or pathophysiological responses of larval hosts. Using a metabolomics approach, we identified a range of metabolic and immunological responses in oyster larvae exposed to OsHV-1 μVar; some of which have not previously been reported in molluscs. Multivariate analyses of entire metabolite profiles were able to separate infected from non-infected larvae. Correlation analysis revealed the presence of major perturbations in the underlying biochemical networks and secondary pathway analysis of functionally-related metabolites identified a number of prospective pathways differentially regulated in virus-exposed larvae. These results provide new insights into the pathogenic mechanisms of OsHV-1 infection in oyster larvae, which may be applied to develop disease mitigation strategies and/or as new phenotypic information for selective breeding programmes aiming to enhance viral resistance.

Similar Items