Lipophilic Toxin Profile in Mytilus galloprovincialis from the North Atlantic Coast of Morocco: LC-MS/MS and Mouse Bioassay Analyses

• Main Authors: Ben Haddouch, Asia, Amanhi, Rachid, Amzil, Zouher, Taleb, Hamib, Rovillon, Georges-augustin, Adly, Farida, Loutfi, Mohammed
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2017
• Subjects: diarrheictoxins; lipophilic toxins; LC-MS/MS; mouse test; shellfish; North Atlantic
• Online Access: https://archimer.ifremer.fr/doc/00372/48342/48495.pdf; https://doi.org/10.21275/24121602; https://archimer.ifremer.fr/doc/00372/48342/

Forthe Moroccan Phycotoxins Monitoring that is part of theSafety of theCoastal Monitoring Network(RSSL),shellfish sampleswereharvestedfromdifferentlocations at NorthAtlantic of Morocco whereharmful algaeblooms were known to have occurred. Forallshellfishsamples found positive by themouse bioassay fordiarrheicshellfishpoisoning(DSP)toxins,liquid chromatography coupled to tandem massspectrometry(LC-MS-MS) in order to search thefollowinglipophilictoxins: okadaic acid (OA), dinophysistoxins(DTXs), pectenotoxins(PTXs), azaspiracids(AZAs), yessotoxins(YTXs), spirolides(SPXs) and gymnodimines (GYMs).Theresultsrevealeddifferentlipophilictoxinprofiles as a function of theshellfish sampling location. It has beennoticed that allthesamples contained OA and its derivativesnamed dinophysistoxins(DTXs). In addition, other lipophilictoxinswerefound in shellfishsamples:(YTXs), and pectenotoxins(PTX-2, PTX-2-seco-acid and 7- epi-PTX-2-seco-acid) on theNorthAtlantic coast .This paper reports on thefirstdetection of YTXs,PTXsGYMs and their derivatives in Moroccan shellfish.