| Summary: | análisis final del proyecto. Ambos requerimientos fueron aprobados (ver anexos). Además, debido a los retrasos que tuvimos producto de la emergencia sanitaria, pudimos finalizar el manuscrito con los resultados principales, el cual se presenta en este informe como enviado (para la aprobación de los coautores), pero no publicado. RESULTS OBTAINED: General goal The primary aim of this study is to compare the effect of resistance-type exercise training on skeletal muscle mass (i.e. quadriceps cross-sectional area and whole body lean mass) in young old and oldest old subjects. Participants In total, 78 participants were screened, but only 31 participants underwent the initial evaluation (T1, before intervention), due to exclusion criteria as well as COVID-19 restrictions during the experimental phase of the study. After voluntary dropout of another 2 people, 29 participants were considered for the final analysis (Figure 1). At baseline, participants in the ELDERLY group (≥85 y) were on average 19 years older than participants in the OLDER group (65-75 y), with no further differences in height, weight, BMI, blood pressure and waist circumference (Table 1). Twelve weeks of resistance-type exercise training induced a small but significant decrease in waist circumference in both the OLDER and ELDERLY group (time: P=0.041; η2=0.11; Table 2), with no differences between groups (time x group: P=0.283). Body weight and BMI did not change throughout the intervention period (Table 2). Dietary intake data are presented in Supplemental Table 1. No significant differences were observed in the macronutrient composition of the diet (all P>0.05). Protein intake averaged 1.1±0.4 and 1.2±0.4 g·kg BW-1·d-1 in the OLDER and ELDERLY participants, respectively. No differences were observed between groups, and no changes were observed over time for any of the dietary intake parameters. Figure 1: Flow diagram of study participants Fondecyt Iniciación FONDECYT de Iniciación 2018 Proyectos de Investigación skeletal muscle ...
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