Lipase-Induced Oxidative Furan Rearrangements

Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of...

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Bibliographic Details
Published in:Synlett
Main Authors: Blume, Fabian, Sprengart, Petra, Deska, Jan
Other Authors: Department of Chemistry and Materials Science, University of Cologne, Aalto-yliopisto, Aalto University
Format: Article in Journal/Newspaper
Language:English
Published: 2018
Subjects:
Achmatowicz
furan
heterocyclic chemistry
pyranone
ring expansion
synthetic methodology
Antarc*
Antarctica
Online Access:https://aaltodoc.aalto.fi/handle/123456789/35290
https://doi.org/10.1055/s-0036-1591889
Description
Summary:Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of N-protected furfurylamines. Peer reviewed

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