Gene expression patterns in Atlantic salmon ( Salmo salar) with severe nephrocalcinosis

Abstract Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon ( Salmo salar ) smolts without and with severe chronic nephrocalcinosis (NC). The study rev...

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Bibliographic Details
Published in:Journal of Fish Diseases
Main Authors: Klykken, Christine, Boissonnot, Lauris, Reed, Anne Katrine, Whatmore, Paul, Attramadal, Kari, Olsen, Rolf Erik
Other Authors: Norges Forskningsråd
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2022
Subjects:
Atlantic salmon
Salmo salar
Online Access:http://dx.doi.org/10.1111/jfd.13687
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfd.13687
https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfd.13687
Description
Summary:Abstract Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon ( Salmo salar ) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival.

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