Primary aldosteronism: from case detection to histopathology with up to 6 years of follow‐up

The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long‐term outcomes after interventions in patients diagnosed with primary aldosteronism ( PA ) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA...

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Bibliographic Details
Published in:The Journal of Clinical Hypertension
Main Authors: Jonsdottir, Gudbjörg, Gudmundsson, Jon, Birgisson, Gudjon, Sigurjonsdottir, Helga Agusta
Other Authors: Landspítali Háskólasjúkrahús
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2016
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Online Access:http://dx.doi.org/10.1111/jch.12947
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjch.12947
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jch.12947
Description
Summary:The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long‐term outcomes after interventions in patients diagnosed with primary aldosteronism ( PA ) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA during the years 2007–2011 at Landspitali Hospital in Iceland, a referral center for the whole country. Workup after detection included salt loading test, positional test, computed tomography, and adrenal vein sampling. Patients with unilateral disease were offered treatment with adrenalectomy. A total of 33 patients were diagnosed with PA during the study period: 17 patients with bilateral disease and 16 with unilateral disease. Results from salt loading test were positive in 90% of patients. In patients with adenoma, 36% were responsive on their positional test and computed tomography scan showed a nodule in 73%. All patients with unilateral disease had a lateralization index ≥3. After surgery, patients had lower systolic blood pressure ( P <.001) and number of hypertensive medications ( P <.01).