Drug Effects on Isolated Artery Strips from Two Teleosts, Gadus morhua and Salmo gairdneri

• Published in: Acta Physiologica Scandinavica
• Main Authors: Holmgren, Susanne, Nilsson, Stefan
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1974
• Subjects: Gadus morhua
• Online Access: http://dx.doi.org/10.1111/j.1748-1716.1974.tb05605.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1974.tb05605.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1974.tb05605.x

Abstract The presence of adrenergic and cholinergic receptors in the celiac arteries of the cod, Gadus morhua , and the rainbow trout, Salmo gairdneri , has been investigated. Affinities and intrinsic activities of different catecholamines and acetylcholine have been determined from cumulative dose‐response curves. The pD 2 ‐value for acetylcholine was 6.62 ± 0.20 in the rainbow trout arteries, while the cod arteries only responded to acetylcholine in concentrations of 10 ‐ ‐ 2 M or more. In both species the potencies of the catecholamines producing contraction of the arteries were in the order adrenaline > noradrenaline > phenylephrine, while isoprenaline did not contract the preparations. In cod arteries competitive antagonism was obtained with yohimbine (pA 2 = 7.3), phentolamine (pA 2 = 8.0) and propranolol (pA 2 = 6.1), while phenoxybenzamine produced non‐competitive blockade of the response to noradrenaline (pM 50 = 6.9). It is concluded that although the rainbow trout celiac artery could possess double innervation, it is unlikely that a cholinergic vasomotor innervation plays any role in regulating the cod celiac artery. A solely adrenergic alpha receptor mediated innervation is therefore proposed for the cod celiac artery.