HLA‐DPB1, ‐DRB1, and ‐DQB1 polymorphism defined in Ewenki ethnic minority of China Inner Mongolia Autonomous Region

Summary In the present study, DNA typing for human leucocyte antigen (HLA)‐DPB1, ‐DRB1, and ‐DQB1 was performed using polymerase chain reaction–sequence‐based‐typing (PCR‐SBT) method on 94 randomly selected, healthy, unrelated individuals from the Ewenki ethnic population in Inner Mongolia Autonomou...

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Bibliographic Details
Published in:International Journal of Immunogenetics
Main Authors: Su, X., Bi, L., Hai, R., Qimuge, S., Ying, M., Bahring, S., Gong, M.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2007
Subjects:
Genetics (clinical)
Genetics
Molecular Biology
General Medicine
Immunology
Ewenki
Online Access:http://dx.doi.org/10.1111/j.1744-313x.2007.00718.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1744-313X.2007.00718.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1744-313X.2007.00718.x
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Summary:Summary In the present study, DNA typing for human leucocyte antigen (HLA)‐DPB1, ‐DRB1, and ‐DQB1 was performed using polymerase chain reaction–sequence‐based‐typing (PCR‐SBT) method on 94 randomly selected, healthy, unrelated individuals from the Ewenki ethnic population in Inner Mongolia Autonomous Region of China. A total of 64 alleles: 25 in DRB1, 19 in DQB1 and 20 in DPB1, were found. Among the 25 detected DRB1 alleles, DRB1*090102, DRB1*030101, DRB1*040101, DRB1*070101, and DRB1*120101/1206 were commonly observed, with frequencies of 16.0%, 13.3%, 10.1%, 7.4%, and 7.4%, respectively. The most predominant DQB1 allele was DQB1*030101/0309 with the frequency of 27.7%, followed by DQB1*0201/0202 (19.7%), DQB1*030302 (12.8%), DQB1*060101/060103 (6.4%), and DQB1*050201 (5.9%). Of the 20 detected DPB1 alleles, DPB1*020102 was the most frequent allele with the frequency of 25.5%. DPB1*0402 (21.3%), DPB1*0401 (20.2%), DPB1*0501 (10.6%) and DPB1*4101 (3.7%) were also very frequent alleles. The most frequent two‐locus haplotypes observed in the Ewenki were: DRB1*030101‐DQB1*0201/0202(10.7%), DRB1*090102‐DQB1*03032(9.8%), DRB1*070101‐DQB1*0201/0202 (5.5%), DRB1*070101‐DQB1*030302 (5.2%) and DRB1*120101/1206‐DQB1*030101/0309 (4.6%). The distribution of the HLA class II alleles and haplotypes frequencies as well as the dendrogram showed that the Ewenki population belongs to the northern group of Chinese.

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