THE ASSOCIATION BETWEEN COELIAC DISEASE, DERMATITIS HERPETIFORMIS AND CERTAIN HLA‐ANTIGENS IN ICELANDERS

SUMMARY Twenty‐eight cases of coeliac disease (CD) and seven of dermatitis herpetiformis (DH) have been verified in Iceland. Standard serological techniques were used for HLA typing. Twenty‐five individuals with CD were typed, 21 (84%) of whom carried DR3, DQ2. Twelve of these 25 (48%) had DR3, DR7,...

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Bibliographic Details
Published in:International Journal of Immunogenetics
Main Authors: ÁRnason, A., Skaftadóttir, I., Sigmundsson, J., MOONEY, E., Björnsson, J., Cariglia, N., Pálsson, G., Gudjónsson, H.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 1994
Subjects:
Genetics (clinical)
Genetics
Molecular Biology
General Medicine
Immunology
Iceland
Online Access:http://dx.doi.org/10.1111/j.1744-313x.1994.tb00218.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1744-313X.1994.tb00218.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1744-313X.1994.tb00218.x
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Summary:SUMMARY Twenty‐eight cases of coeliac disease (CD) and seven of dermatitis herpetiformis (DH) have been verified in Iceland. Standard serological techniques were used for HLA typing. Twenty‐five individuals with CD were typed, 21 (84%) of whom carried DR3, DQ2. Twelve of these 25 (48%) had DR3, DR7, DQ2, which makes them possibly homozygous for DQ2, and suggests that homozygosity of DQ2 increases the risk for CD. The four DH patients that were typed all had HLA‐B8, DR3, DQ2. It is concluded that CD and DH are associated with DR3, DQZ in Icelanders.

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