Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population
We have examined the association of phosphodiesterase 4D ( PDE4D ) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818‐1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly...
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crwiley:10.1111/j.1468-1331.2007.01767.x 2024-06-09T07:47:09+00:00 Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population Fidani, L. Clarimon, J. Goulas, A. Hatzitolios, A. I. Evans, W. Tsirogianni, E. Hardy, J. Kotsis, A. 2007 http://dx.doi.org/10.1111/j.1468-1331.2007.01767.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-1331.2007.01767.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1331.2007.01767.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Neurology volume 14, issue 7, page 745-749 ISSN 1351-5101 1468-1331 journal-article 2007 crwiley https://doi.org/10.1111/j.1468-1331.2007.01767.x 2024-05-16T14:27:43Z We have examined the association of phosphodiesterase 4D ( PDE4D ) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818‐1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818‐1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke. Article in Journal/Newspaper Iceland Wiley Online Library European Journal of Neurology 14 7 745 749 |
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Wiley Online Library |
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crwiley |
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English |
description |
We have examined the association of phosphodiesterase 4D ( PDE4D ) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818‐1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818‐1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke. |
format |
Article in Journal/Newspaper |
author |
Fidani, L. Clarimon, J. Goulas, A. Hatzitolios, A. I. Evans, W. Tsirogianni, E. Hardy, J. Kotsis, A. |
spellingShingle |
Fidani, L. Clarimon, J. Goulas, A. Hatzitolios, A. I. Evans, W. Tsirogianni, E. Hardy, J. Kotsis, A. Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
author_facet |
Fidani, L. Clarimon, J. Goulas, A. Hatzitolios, A. I. Evans, W. Tsirogianni, E. Hardy, J. Kotsis, A. |
author_sort |
Fidani, L. |
title |
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
title_short |
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
title_full |
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
title_fullStr |
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
title_full_unstemmed |
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
title_sort |
association of phosphodiesterase 4d gene g0 haplotype and ischaemic stroke in a greek population |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1111/j.1468-1331.2007.01767.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-1331.2007.01767.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1331.2007.01767.x |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
European Journal of Neurology volume 14, issue 7, page 745-749 ISSN 1351-5101 1468-1331 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1468-1331.2007.01767.x |
container_title |
European Journal of Neurology |
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14 |
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7 |
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745 |
op_container_end_page |
749 |
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1801378076585623552 |