Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population

• Published in: European Journal of Neurology
• Main Authors: Fidani, L., Clarimon, J., Goulas, A., Hatzitolios, A. I., Evans, W., Tsirogianni, E., Hardy, J., Kotsis, A.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2007
• Subjects: Iceland
• Online Access: http://dx.doi.org/10.1111/j.1468-1331.2007.01767.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-1331.2007.01767.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1331.2007.01767.x

We have examined the association of phosphodiesterase 4D ( PDE4D ) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818‐1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818‐1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.