Low frequency of the disease‐associated DRB1*15‐DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami
Abstract This study confirms a low frequency of multiple sclerosis (MS) among Sami. Only 12 Sami with a diagnosis of MS were identified in the Norwegian Sami population, which represents a significantly lower prevalence of MS in Sami (30/10 5 ) compared with other Norwegians (73–164/10 5 ). The clin...
Published in: | Tissue Antigens |
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Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2007
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Subjects: | |
Online Access: | http://dx.doi.org/10.1111/j.1399-0039.2007.00803.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.2007.00803.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.2007.00803.x |
Summary: | Abstract This study confirms a low frequency of multiple sclerosis (MS) among Sami. Only 12 Sami with a diagnosis of MS were identified in the Norwegian Sami population, which represents a significantly lower prevalence of MS in Sami (30/10 5 ) compared with other Norwegians (73–164/10 5 ). The clinical characteristics as well as the results of human leukocyte antigen (HLA)‐DRB1 and ‐DQB1 typing of the Sami MS patients are reported, showing that three (27%) of the Sami MS patients carried the MS‐associated HLA‐DRB1*15‐DQB1*06 haplotype. Interestingly, the DRB1*15‐DQB1*06 haplotype had a significantly reduced frequency among Sami controls (0.086) compared with non‐Sami Norwegian controls (0.163) ( P corrected = 0.015). The low frequency of the disease‐associated DRB1*15‐DQB1*06 haplotype in the Sami population may contribute to the low prevalence of MS in Sami, in addition to other yet unidentified genetic and environmental factors. |
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