Conservation of MHC class II DOA sequences among carnivores*
Abstract: We obtained the nucleotide sequence for most of the major histocompatibility complex (MHC) class II DOA locus for Weddell, leopard, northern elephant, and southern elephant seals and from the coyote and compared them to all known DOA data available to date. We found generally low levels of...
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crwiley:10.1111/j.1399-0039.2005.00371.x 2024-10-13T14:06:56+00:00 Conservation of MHC class II DOA sequences among carnivores* Soll, S.J. Stewart, B.S. Lehman, N. 2005 http://dx.doi.org/10.1111/j.1399-0039.2005.00371.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.2005.00371.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.2005.00371.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Tissue Antigens volume 65, issue 3, page 283-286 ISSN 0001-2815 1399-0039 journal-article 2005 crwiley https://doi.org/10.1111/j.1399-0039.2005.00371.x 2024-09-17T04:46:41Z Abstract: We obtained the nucleotide sequence for most of the major histocompatibility complex (MHC) class II DOA locus for Weddell, leopard, northern elephant, and southern elephant seals and from the coyote and compared them to all known DOA data available to date. We found generally low levels of interspecific polymorphisms, providing further support for stabilizing selection acting on the DOA locus. This suggests that DO gene products play a substantial functional role in the regulation of antigen presentation. A seven–amino‐acid motif of VWRLPEF was found to be conserved across all DOA sequences and may be a DO‐specific recognition element. Article in Journal/Newspaper Elephant Seals Southern Elephant Seals Wiley Online Library Weddell Tissue Antigens 65 3 283 286 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract: We obtained the nucleotide sequence for most of the major histocompatibility complex (MHC) class II DOA locus for Weddell, leopard, northern elephant, and southern elephant seals and from the coyote and compared them to all known DOA data available to date. We found generally low levels of interspecific polymorphisms, providing further support for stabilizing selection acting on the DOA locus. This suggests that DO gene products play a substantial functional role in the regulation of antigen presentation. A seven–amino‐acid motif of VWRLPEF was found to be conserved across all DOA sequences and may be a DO‐specific recognition element. |
format |
Article in Journal/Newspaper |
author |
Soll, S.J. Stewart, B.S. Lehman, N. |
spellingShingle |
Soll, S.J. Stewart, B.S. Lehman, N. Conservation of MHC class II DOA sequences among carnivores* |
author_facet |
Soll, S.J. Stewart, B.S. Lehman, N. |
author_sort |
Soll, S.J. |
title |
Conservation of MHC class II DOA sequences among carnivores* |
title_short |
Conservation of MHC class II DOA sequences among carnivores* |
title_full |
Conservation of MHC class II DOA sequences among carnivores* |
title_fullStr |
Conservation of MHC class II DOA sequences among carnivores* |
title_full_unstemmed |
Conservation of MHC class II DOA sequences among carnivores* |
title_sort |
conservation of mhc class ii doa sequences among carnivores* |
publisher |
Wiley |
publishDate |
2005 |
url |
http://dx.doi.org/10.1111/j.1399-0039.2005.00371.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.2005.00371.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.2005.00371.x |
geographic |
Weddell |
geographic_facet |
Weddell |
genre |
Elephant Seals Southern Elephant Seals |
genre_facet |
Elephant Seals Southern Elephant Seals |
op_source |
Tissue Antigens volume 65, issue 3, page 283-286 ISSN 0001-2815 1399-0039 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0039.2005.00371.x |
container_title |
Tissue Antigens |
container_volume |
65 |
container_issue |
3 |
container_start_page |
283 |
op_container_end_page |
286 |
_version_ |
1812813189531828224 |