Conservation of MHC class II DOA sequences among carnivores*

Abstract: We obtained the nucleotide sequence for most of the major histocompatibility complex (MHC) class II DOA locus for Weddell, leopard, northern elephant, and southern elephant seals and from the coyote and compared them to all known DOA data available to date. We found generally low levels of...

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Bibliographic Details
Published in:Tissue Antigens
Main Authors: Soll, S.J., Stewart, B.S., Lehman, N.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2005
Subjects:
Weddell
Elephant Seals
Southern Elephant Seals
Online Access:http://dx.doi.org/10.1111/j.1399-0039.2005.00371.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.2005.00371.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.2005.00371.x
Description
Summary:Abstract: We obtained the nucleotide sequence for most of the major histocompatibility complex (MHC) class II DOA locus for Weddell, leopard, northern elephant, and southern elephant seals and from the coyote and compared them to all known DOA data available to date. We found generally low levels of interspecific polymorphisms, providing further support for stabilizing selection acting on the DOA locus. This suggests that DO gene products play a substantial functional role in the regulation of antigen presentation. A seven–amino‐acid motif of VWRLPEF was found to be conserved across all DOA sequences and may be a DO‐specific recognition element.

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