Increased frequency of HLA‐DRwl4b(w6)‐associated RFLP in Greenlanders of Eskimo origin

Abstract: HLA‐DR typing by the restriction fragment length polymorphism (RFLP) technique of 42 Greenlanders living in northern Jutland, Denmark, revealed a phenotype frequency of 33.3% for HLA‐DRwl4b(w6), which is significantly different from the frequency of 0.0% observed among 98 Danes of Caucasia...

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Bibliographic Details
Published in:Tissue Antigens
Main Authors: Grunnet, N., Steffensen, R., Jersild, C.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 1991
Subjects:
eskimo*
greenlander*
Online Access:http://dx.doi.org/10.1111/j.1399-0039.1991.tb01857.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1991.tb01857.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1991.tb01857.x
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Summary:Abstract: HLA‐DR typing by the restriction fragment length polymorphism (RFLP) technique of 42 Greenlanders living in northern Jutland, Denmark, revealed a phenotype frequency of 33.3% for HLA‐DRwl4b(w6), which is significantly different from the frequency of 0.0% observed among 98 Danes of Caucasian origin. When comparing the two populations, the frequency of other HLA‐DRB allogenotypes show insignificant variations. Since HLA‐DRwl4b(w6) is carried by approximately one‐third of the Greenlanders tested, this allogenotype may serve as a useful marker in further anthropological and immunogenetic studies.

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