Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations

Summary Allelic frequencies at the three most polymorphic loci of the HLA class II region (DRB1, DQA1 and DQB1) were determined in the Nganasan and Ket, the remnants of the two most ancient groups in the Lower Yenisey River/Taimyr Peninsula region in northern Siberia. By single‐stranded conformation...

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Bibliographic Details
Published in:European Journal of Immunogenetics
Main Authors: Uinuk‐ool, T. S., Takezaki, N., Derbeneva, O. A., Volodko, N. V., Sukernik, R. I.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2004
Subjects:
Yenisey
Nganasan*
Taimyr
yenisey river
Siberia
Online Access:http://dx.doi.org/10.1111/j.1365-2370.2004.00443.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2370.2004.00443.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2370.2004.00443.x
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Summary:Summary Allelic frequencies at the three most polymorphic loci of the HLA class II region (DRB1, DQA1 and DQB1) were determined in the Nganasan and Ket, the remnants of the two most ancient groups in the Lower Yenisey River/Taimyr Peninsula region in northern Siberia. By single‐stranded conformational polymorphism typing, verified by sequencing, 19 HLA‐DRB1‐DQA1‐DQB1 haplotypes and 15 HLA‐DRB1, seven DQA1 and 11 DQB1 alleles were found. The most frequent alleles were DRB1*1301 (23.5%), DQA1*0103 (29.4%), *0501/03/05 (29.4%), and DQB1*0301/09 (32.4%) in the Ket, and DRB1*0901 (25%), DQA1*0301 (39.6%), and DQB1*0301/09 (37.5%) in the Nganasan. The distribution patterns and comprehensive phylogenic analysis based on the haplotype frequencies of 17 Siberian populations suggest that the founders of both the Ket and the Nganasan came from Palaeolithic populations in the Altai‐Sayan Upland.

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